Genomic changes in the infectious yeast Candida tropicalis may play a role in its resistance to antifungals, according to a study published in PLOS Biology. The work, led by Guanghua Huang at Fudan University, China, and colleagues, shows that these genomic changes can be brought on by a common antifungal, TBZ. The study demonstrates that the use of TBZ in agriculture may contribute to the increasing problem of antifungal resistance.